Salvianolic acid B (SalB) is a major water-soluble phenolic compound with reported antioxidant and metabolic regulatory properties. We investigated its hepatoprotective effects in AML12 cells exposed to high glucose and palmitic acid (HG-PA), an in vitro model of diabetes-associated non-alcoholic fatty liver disease. SalB showed minimal cytotoxicity and significantly improved cell viability after HG-PA challenge. It reduced mitochondrial reactive oxygen species and 4-hydroxynonenal accumulation, indicating attenuation of oxidative stress and lipid peroxidation. SalB also restored MitoTracker fluorescence and intracellular ATP levels, consistent with improved mitochondrial function and cellular bioenergetics. HG-PA increased cereblon (CRBN) expression and suppressed AMPKα phosphorylation, whereas SalB partially reversed both changes. These findings suggest that SalB protects hepatocytes from glucolipotoxic injury by limiting oxidative damage, preserving mitochondrial function, and restoring CRBN-associated AMPK signaling.
Hải Yến Ngô Thị, Khá Phạm Trọng, Thủy Vũ Thị et al.· Tạp chí Sinh lý học Việt Nam· 0 citations
Artificial intelligence recommendations must do more than reproduce a consumer’s established preferences: they must also facilitate worthwhile discovery without undermining confidence in the platform. Drawing on the stimulus–organism–response framework, this study examines recommendation accuracy and recommendation novelty as two distinct system cues, perceived value and trust as parallel cognitive mechanisms, and online purchase intention as the behavioral response. The model was tested with 493 complete survey responses and 27 reflective indicators using partial least squares structural equation modeling in SmartPLS 4. Recommendation accuracy and novelty were positively related to both perceived value and trust. Perceived value, in turn, had a positive relationship with purchase intention. Trust also had a positive but comparatively weak relationship with purchase intention; this path met the conventional percentile-bootstrap criterion, although its bias-corrected confidence interval included zero. The specific indirect effects through perceived value were supported for both accuracy and novelty, whereas the corresponding trust-based indirect effects were not supported under conservative inference. The model explained 7.5% of perceived value, 3.4% of trust, and 4.0% of purchase intention, indicating that recommendation quality is a meaningful but limited part of the wider purchase decision. The findings distinguish relevance from discovery and show that the value pathway is more dependable than the trust pathway in translating AI recommendation quality into purchase intention.
Bích Đào Phạm Thị· International Journal of Adv...· 0 citations
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