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Author

Billy Wai-Lung Ng

2 papers indexed here

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Open access Sep 2026

Molecular Editing of Bilobalide: Expanding Chemical Space and Biological Opportunities

Complex natural products often show promising biological activity but suffer from liabilities, such as chemical or metabolic instability, that can limit their therapeutic evaluation. This perspective highlights bilobalide as a case study for how targeted molecular editing can transform a fragile, structurally dense n...

Stephan Scheeff, C. Sillapachaiyaporn, Billy Wai-Lung Ng · 0 citations
Sep 2026

Targeted O-GlcNAcylation enables functional rewiring of c-Myc.

Chemically induced proximity has transformed targeted protein degradation but has been applied far less extensively to directly reprogram protein function through post-translational modification (PTM). Here, we develop an O-GlcNAcylation-targeting Chimera (OGTAC) that recruits O-GlcNAc transferase (OGT) to the oncogeni...

Tong-Yang Xu, Zhi-Hao Guo, K. S. Khan et al. · 0 citations

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