NPAS2 promotes MASLD and hepatocarcinogenesis through SIRT1-mediated PPARγ suppression
Emerging evidence links circadian disruption to metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying mechanisms remain elusive. NPAS2, a core circadian regulator, has an undefined role in the pathogenesis of MASLD and its progression to hepatocellular carcinoma (HCC). This study aime...