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Author

Bin Gu

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Aug 2026

An Amplified Luminescent Proximity Homogeneous Assay-Implemented CRISPR/Cas13a System for Noncoding RNA Detection

The Alpha-CRISPR RNA detection system developed in this study integrates AlphaLISA technology with the CRISPR-Cas13a system, achieving significantly enhanced detection sensitivity, demonstrating substantial application potential in fundamental medical research and clinical diagnostics.

Yaofan Lu, Zhen-Ya Cheng, Zheng Wang et al. · 0 citations
Open access Aug 2026

Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella

This study identifies that upon the elevation of intracellular c-di-GMP levels induced by antibiotic treatmen, the universal stress protein UspG serves as a cryptic, direct c-di-GMP effector in extended-spectrum beta-lactamase (ESBL)-producing strain K. pneumoniae, and indicates that UspG is functionally conserved acro...

Xiao-Xiao Liu, Mingfang Wang, Yi-Kai Fu et al. · 0 citations
Aug 2026

Logic-Gated Dual-Aptamer Proximity AlphaLISA for Rapid and Sensitive Detection of Tumor-Derived Small Extracellular Vesicles.

This programmable dual-aptamer amplified luminescent proximity homogeneous assay (AlphaLISA) provides a rapid, homogeneous, and highly adaptable strategy for tumor-derived sEVs analysis, offering promising potential for noninvasive cancer diagnostics.

Shangbin Kao, Nannan Tian, Yaping Zhang et al. · 0 citations

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