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Sep 2026

Configuration and Molecular Flexibility Regulated Reactive Oxygen Species Type and Efficiency for Potent Anticancer Performance: A BODIPY-Pt(II) Complex Case

Regulating type-I and type-II photochemistry is essential for anticancer photodynamic therapy. Type-I pathways generate hydroxyl and superoxide radicals, whereas type-II produces singlet oxygen. We tuned reactive oxygen species (ROS) generation by varying Pt(II) configuration and ligand flexibility. Among the four co...

Hui Chong, Guang-Jie Zhong, Xiang Sun et al. · 0 citations
Open access Aug 2026

A glucose metabolism-targeted nanoplatform amplifies disulfidptosis-associated immunogenic cell death in triple-negative breast cancer

Disulfidptosis is a metabolism-dependent form of cell death driven by disulfide stress that induces actin cytoskeletal collapse in SLC7A11-high cells under glucose deprivation. However, strategies to therapeutically exploit this vulnerability remain underdeveloped. Given the high dependence of triple-negative breast ca...

Jia-Lin Xu, Yanting Sun, Bin Huang et al. · 0 citations

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