AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Functional and genetic perturbations establish that klRNAs suppress host intron excision through a K-loop-dependent mechanism and establish klRNA-mediated autoregulation as a widespread principle governing intron fate.
Introns occupy nearly one-third of the human genome, yet whether they encode widespread regulatory functions remains unclear. Here, we identify a pervasive class of intron-derived Kink-loop RNAs (klRNAs) that locally control pre-mRNA processing. Using complementary enrichment strategies, we uncovered approximately 15,2...
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