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Author

Bin Peng

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Nov 2026

Cathepsin S drives keratinocyte IL-8/ICAM-1-mediated neutrophilic inflammation in generalized pustular psoriasis and induces a pustular psoriasis-like phenotype in mice.

BACKGROUND Generalized pustular psoriasis (GPP) is a severe autoinflammatory dermatosis driven by excessive IL-1/IL-36-neutrophil activation, with high disease burden and limited therapeutic options. The mechanisms underlying dysregulated neutrophil recruitment remain incompletely understood, and the lack of mechanisti...

Xiang-Jin Song, De-Lu Che, Bin Peng et al. · 0 citations

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