Author

Bin Zhang

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Jul 2026

EIF4A3-dependent nonsense-mediated decay buffers AML1-ETO9a dosage and modulates outcome in t(8;21) acute myeloid leukemia

EIF4A3-dependent NMD is defined as a checkpoint linking RNA surveillance to oncogenic fusion-isoform dosage, leukemic fitness, and chemosensitivity in t(8;21) AML, providing a mechanistic explanation for clinical heterogeneity in t(8;21) AML.

Min Zhang, Yisheng Li, Bin Zhang et al. · Leukemia · 1 citation