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Open access Sep 2026

Imeglimin improves mitochondrial quality and protects against lipopolysaccharide-induced acute lung injury by enhancing TXNIP promoter methylation.

This study explores the protective effects and mechanistic pathways of imeglimin in models of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Imeglimin administration significantly enhanced survival rates, mitigated pulmonary edema, and attenuated histopathological lung damage in murine subjects. Furthermore,...

Dan-Dan Li, Yu-Zhou Xiao, Wei-Long Hong et al. · 0 citations
Open access Aug 2026

Effects of Dexmedetomidine on Respiratory Mechanics in Elderly Patients Undergoing Laparoscopic Colorectal Tumor Resection: A Randomized Double-Blinded Trial

Background Perioperative pulmonary dysfunction frequently occurs in elderly patients undergoing procedures involving pneumoperitoneum and the Trendelenburg position. This study aimed to evaluate the effect of Dex on respiratory mechanics in elderly patients undergoing laparoscopic resection of colorectal tumors. Method...

Lin Yang, Yongheng Cai, R. Tan et al. · 0 citations

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