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Bing-Chen Duan

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#artificial intelligence Preprint Nov 2026

ProteoCraft: Protein Design as Proposal-Verification Search

Protein-protein interactions underpin nearly all biological processes. Yet, designing proteins with desired interactions remains challenging due to the structural complexity governing molecular recognition. This study views protein design as a search optimization problem over a combinatorial sequence space under expens...

Fang Wu, Hong-Bin Lin, Bing-Chen Duan et al. · 0 citations
Review Open access Sep 2026

Inhibitory receptor profiles for joint prediction of benefit and toxicity in immune checkpoint blockade

Summary Immune checkpoint blockade has transformed cancer therapy, but durable benefit is limited to a subset of patients and can be accompanied by immune-related adverse events. This Review evaluates inhibitory receptor profiles as candidate biomarkers for predicting both antitumor benefit and immune toxicity. We exam...

Xiao-Dong Wang, Di Xiong, Bing-Chen Duan et al. · 0 citations

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