Lyme neuroborreliosis (LNB), caused by Borrelia garinii, often leads to persistent neurological deficits, yet early diagnosis remains insensitive and the temporal metabolic changes in the infected brain are largely unexplored. In this study, a murine model of B. garinii infection was established using 80 female BALB/c...
Bin-Tao Zhai, Q. Niu, Hui Yang et al.· Biomolecules· 0 citations
The rise in antimicrobial resistance (AMR) demands new treatments, especially for biofilm-associated infections where bacteria tolerate antibiotics. Escherichia coli O157:H7 (E. coli O157) is a virulent foodborne pathogen that causes severe haemorrhagic colitis and haemolytic uraemic syndrome. The LuxS/AI-2 quorum sens...
Hong-Xing Zhang, Jing Xu, Wen-Kui Bao et al.· Biomolecules· 0 citations
Background Conventional bactericidal antibiotics often fail to eradicate Escherichia coli O157:H7 (E. coli O157) infections due to biofilm-mediated antimicrobial tolerance, and monotherapy can inadvertently drive resistance selection. This study aimed to identify compounds capable of modulating LuxS/AI-2-related phenot...
Hong-Xing Zhang, Jing Xu, Ya-Xin Zhou et al.· Frontiers in Microbiology· 0 citations
Pseudomonas aeruginosa employs quorum sensing (QS) to coordinate biofilm formation and virulence factor expression, positioning QS as a promising target for anti-infective interventions. This study evaluated the antibiofilm and antivirulence efficacy of 2-methoxy-1,4-naphthoquinone (MNQ), a natural naphthoquinone, agai...
ICAC may potentiate the antibacterial activity of ciprofloxacin through targeting of OmpF, which disrupts bacterial membrane integrity and energy metabolism, providing a promising candidate strategy for combating infections caused by the tested antibiotic-resistant E. coli.
Yu-Bin Bai, Xu Chen, Rong-Bin Hu et al.· Biomolecules· 0 citations
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