Bing Li

Challenges and approaches to the design of hydrophilic linkers for antibody-drug conjugates.

Antibody-drug conjugates (ADCs) are now established approaches to the development of precision-guided therapeutics, yet some of the clinical translation effort has been constrained by a paradox at the heart of their design, that is the most effective cytotoxic payloads are also among the most hydrophobic. This intrinsi...