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Bing-Ru Fan

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Aug 2026

Network Pharmacology and Experimental Validation of a Securidaca inappendiculata Xanthone Fraction Targeting Rheumatoid Arthritis via the PI3K/AKT/mTOR/HIF-1α/GSK-3β Axis.

This work elucidated the anti-RA mechanism of S. inappendiculata: eight xanthones acted on the PI3K/AKT/mTOR/HIF-1α/GSK-3β axis to induce M1 macrophage apoptosis, validating the integrated approach and laying groundwork for RA treatment and natural product research.

Xuan Chen, Bing-Ru Fan, Ting Wang et al. · 0 citations

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