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Open access Oct 2026

Tacrolimus attenuates BCL-2/BAX-mediated chondrocyte apoptosis and cartilage matrix degradation in experimental osteoarthritis

Osteoarthritis is a progressive whole-joint disease characterized by cartilage matrix degradation, synovial inflammation and impaired chondrocyte survival. Current pharmacological treatments mainly relieve symptoms and do not reliably prevent structural progression. Here, we investigated whether tacrolimus, a clinicall...

Hua-Ze Zhu, Yun Chen, B. Ruan et al. · 0 citations
Review Open access Aug 2026

Comparative effectiveness and dose–response relationship of exercise-based interventions for muscle mass in older women with sarcopenia: a systematic review and network meta-analysis

Background Exercise and nutrition are the principal non-pharmacological strategies for sarcopenia, but the relative effects of different exercise combinations and the dose required to improve muscle mass in older women remain uncertain. This study compared exercise-based interventions and examined the dose-response rel...

Xin-Yi Gou, Jun-Hui Zhu, Xin-Miao Feng et al. · 0 citations

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