Review
Open access
Sep 2026
Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design
A biomarker-guided strategy that combines tumor visibility, immune-cell state, spatial architecture, systemic inflammation, and early treatment dynamics to identify the dominant resistance topology is proposed to restore productive immune pressure while limiting compensatory escape and toxicity.
Xiao-Dong Wang, Jia-Yi Liu, Alifujiang Hairulajiang et al.
· Molecular Cancer · 0 citations