Open access
Sep 2026
The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss.
BRCA1-linked cancers contain abundant ~10 kb 'Group 1' tandem duplications (TDs). Group 1 TDs form at a Tus/Ter replication-fork barrier in DNA-end resection-defective mouse embryonic stem (mES) cells lacking Brca1 exon 11. To elucidate how BRCA1 suppresses Group 1 TDs, we analyzed Brca1 coiled-coil (CC)-domain mutants...
N. Nilavar, Alberto Marin-Gonzalez, F. Menghi et al.
· EMBO Journal · 0 citations