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Aug 2026

Palladium-Catalyzed Asymmetric Synthesis of Methylidene Cyclobutanes via Enantioselective Intramolecular Heck-Type Reactions.

Cyclobutanes as well as 2-substituted alkylidene cyclobutanes (ADCBs) are important skeletons in pharmaceuticals and versatile precursors in organic synthesis. However, enantioselective synthesis of ADCBs remains an underexplored area of research due to the high ring strain and competing side reactions. Herein, we repo...

Hao Yu, Bing Xu, Jun-Liang Zhang et al. · 1 citation
Aug 2026

Asymmetric Allylic Dearomatization of Quinolines via Dynamic Ligand Exchange.

The strong coordination of quinolines to transition metals typically interferes with chiral catalysts, restricting their use in asymmetric synthesis. Here, we harness this challenging property as a stereocontrol element through the integration of dynamic ligand exchange with designed hydrogen-bonding interactions betwe...

Jianfeng Xu, Li Zhou, Xue-Pei Bai et al. · 0 citations

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