Review
Open access
Oct 2026
Targeting TEAD in cancers: paralog-specific biology, resistance and therapeutic opportunities
Examination of TEA domain transcription factors TEAD molecular architecture, physiological functions and paralog-specific biology, together with canonical regulation by NF2/Merlin and the Hippo kinase cascade and non-canonical inputs from mechanical cues, oncogenic signaling, metabolism and hypoxia, suggests the therap...
Jia-Lin Wu, Fu-Da Xie, Bo-Nan Chen et al.
· Molecular Cancer · 0 citations