Bing-Yu Cao

Single-cell transcriptomics and a boundary wound model reveal temporal decoupling and microenvironmental heterogeneity in radiation-induced fibrosis

Background Radiotherapy is a key treatment method for cancer, but high-dose treatment can lead to damage to normal tissues and chronic fibrosis. There is a lack of systematic temporal analysis of the dynamic progression from early damage signals to late extracellular matrix (ECM) deposition. Methods and materials We re...