Open access
Jul 2026
Social isolation disrupts prefrontal excitatory-inhibitory balance to impair social novelty memory in adult male mice.
It is established that adult social isolation disrupts social novelty memory processing by shifting the mPFC excitatory-inhibitory balance toward a net hyperexcitable state, revealing a reversible, circuit-specific mechanism for isolation-induced social cognitive deficits.
Quan Yuan, Bing-Yu Ren, Laijian Wang et al.
· Translational Psychiatry · 1 citation