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Bing-Yu Zhou

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Sep 2026

Discovery and characterization of PGC-01: An effective GSDMD-targeting PROTAC.

As the key executioner protein of pyroptosis, GSDMD represents a promising yet underexplored therapeutic target for inflammatory diseases. In this study, we explored a PROTAC-based degradation approach targeting GSDMD for the treatment of pyroptosis-driven inflammatory conditions. Through screening of our in-house comp...

Qian-Qian Wang, Rong-Ying Hou, Yi-xuan Shua et al. · 0 citations

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