Investigation of the Immunological Profile of Children with Infectious Mononucleosis
Highlights What are the main findings? Children with acute IM show marked CD8+ T- and NK cell expansion with a broad, Th1-skewed cytokine elevation (IL-12p70 unchanged). Granzyme B and perforin are strongly upregulated in CD8+ T and NK cells, indicating a pronounced cytotoxic-effector phenotype. What are the implicatio...