Split-Type Microneedles Loaded with miR-125b-Enriched Extracellular Vesicles: A Sustained Preventive and Therapeutic Platform for Nitrogen Mustard-Induced Skin Injuries.
Nitrogen mustard (NM) induces severe, refractory skin injuries lacking specific available therapeutics. Considering that extracellular vesicles (EVs) show promising effects in wound healing, we developed a split-type microneedle (MN-EVs@miR) loaded with miR-125b-enriched engineered EVs (EVs@miR) to treat NM-induced ski...