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Bingtong Feng

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Open access Aug 2026

Discovery of a taxusin-mediated route to baccatin III enables its complete biosynthesis in engineered microbes

Taxol (paclitaxel) is a frontline anticancer drug widely applied for the treatment of breast, ovarian and lung cancers. Currently, its supply mainly relies on the semi-synthesis using baccatin III from Taxus plants. Heterologous biosynthesis of baccatin III in microorganisms offers a promising solution to alleviate glo...

Chengshuai Yang, Zhenhua Li, Linjie Yu et al. · 0 citations

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