Summary Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal growth and maturation, as well as in maintaining synaptic plasticity. Dysregulated BDNF levels significantly increase the risk of neurological and metabolic disorders. In type 2 diabetes mellitus, several pathological mechanisms, inclu...
Garima Chandak, B. Kumar, Shubham Kumar et al.· iScience· 0 citations
Although phosphorus is a macronutrient necessary for plant growth, it is mostly present in
soil as insoluble compounds, which prevent plants from using it. Because they enable plants to access
insoluble phosphorus through various biochemical pathways, Phosphate-Solubilizing Microorganisms
(PSMs) are crucial for sus...
Amrita Jana, Anushka Sasmal, Sk. Maksuda et al.· Current Journal of Microbiol...· 0 citations
Introduction: Rich in vitamins, minerals, and bioactive phytochemicals, vegetables have
a major positive impact on human health. However, cooking techniques have a significant impact
on their nutritional content because they can either increase the bioavailability of specific chemicals
or degrade sensitive element...
Sk. Maksuda, Amrita Jana, Lisha Sadhukhan et al.· Letters in Functional Foods· 0 citations
Diabetic neuropathy (DN), a long-term and progressive complication of diabetes mellitus, impairs approximated half of patients with diabetes and affects the quality of life considerably because of pain, sensory deficiency, and motor deficits. Traditional treatment including anticonvulsants, antidepressants, and opioids...
K. Das, Biplab Debnath, Saikat Sen· Journal of drug targeting (P...· 0 citations
Current research on the functional traits of PGPR derived from mangroves, including nutrient solubilization, phytohormone production, ACC deaminase activity, and production of metabolites that aid stress alleviation are reviewed.
Suman Mandal, Debasmita Paul, Anushka Sasmal et al.· Current Journal of Microbiol...· 0 citations
This review highlights the molecular and pathological mechanisms of cGAS-STING signaling in a broader aspect of neurological disorders and appraises the novel therapeutics already under development to inhibit this pathway to regulate neuroinflammation and enhance neurological outcomes.
Abdul Rahim, Shaik Mahammad Zubair, M. Ahamed et al.· Journal of Neuroimmune Pharm...· 0 citations
Rational design strategies for rhodanine-based heterocycles and their therapeutic potential as antibacterial, anti-diabetes, anti-Alzheimer’s, anticancer, anthelmintic, anti-obesity, and against COVID-19 are discussed.
R. Nath, Lakshminarayan Das, Arka Chakraborty et al.· Phosphorus Sulfur and Silico...· 0 citations
This review covers advances in designing and synthesizing bioactive heterocycles, highlighting structure-based drug design (SBDD) and ligand-based drug design (LBDD) approaches with computational modeling and Artificial Intelligence (AI) to find potent, selective molecules with good Absorption, Distribution, Metabolism...
Debajit Dewan, Bhupender Nehra, R. Nath et al.· Future Medicinal Chemistry· 0 citations
A contemporary assessment of biological macromolecule research is provided, highlighting how technological advancements continue to fill the existing bridge and integrate the prior understanding of complex biomolecular systems while addressing persistent technical challenges in their characterization, with finesse.
Rabab Fatima, Bhupender Nehra, Biplab Debnath et al.· Critical reviews in analytic...· 0 citations
This review highlights mechanisms, recent advances, and translational challenges of natural PS‐based nanotherapeutics across multiple cancers, emphasizing strategies to improve delivery, selectivity, and therapeutic outcomes for next‐generation PDT.
