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Author

Birgit Schilling

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Open access Sep 2026

Acute LINE-1 overexpression rewires the transcriptome, proteome and secretome of primary human fibroblasts

A large portion of eukaryotic genomes is composed of transposable elements, which are usually kept repressed in young, healthy cells but can be derepressed in response to cell senescence and organismal aging. LINE-1 (L1) is the most abundant TE in the human genome by percent coverage, and its derepression has been impl...

Juan I. Bravo, Eyael Tewelde, C. D. King et al. · 0 citations

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