Open access
Sep 2026
TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition.
Precise temporal activation of mitotic genes is essential for proper cell-cycle progression, yet the chromatin-based mechanisms coordinating this process remain incompletely understood. The B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and becomes hyperactivated following inhibition of the ATR-...
Franziska Liss, D. Gertzmann, Devi Bala Murugan et al.
· Cell Reports · 1 citation