Author

Bjoernar Tuftin

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Open access Sep 2026

Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes

Summary Chronic, low-grade systemic inflammation is a polygenic trait captured with the INFLA-score, a composite of C-reactive protein, platelet count, leukocyte count, and granulocyte-to-lymphocyte ratio. We derived a polygenic risk score from the INFLA-score (iPRS) in a multi-ancestry population from the UK Biobank (...

H. Jandu, Ayo Olowofela, Megan M. Shuey et al. · HGG advances · 0 citations

Open access Aug 2026

Stress-Related Methylation Risk Scores Predict Coronary Heart Disease

This study supports methylation risk scores as novel biomarkers of stress-related CHD and uncovers epigenetic regulation in monocytes as a potential underlying mechanism of stress-related CHD, highlighting biological pathways linking stress and disease and may promote personalized interventions in high-risk populations...

Sofia Benavides, Hazel Milla, Helena Palma-Gudiel et al. · medRxiv · 0 citations