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Author

Blaise Gatin-Fraudet

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Open access Aug 2026

Emergence of new function through evolutionary divergence of an intrinsically disordered region

Intrinsically disordered regions (IDRs) are major drivers of protein functional diversification, yet the molecular features that enable the emergence of new functions within disordered sequences remain poorly understood. FCHO1 and FCHO2 are paralogous pioneer proteins of clathrin-mediated endocytosis that share a conse...

Carlos A. Elena-Real, Antonia M. Körber, Blaise Gatin-Fraudet et al. · 0 citations

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