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Open access Sep 2026

Bumetanide Strengthens Residual Brain–Bladder Communication After Spinal Cord Injury

Neurogenic bladder is one of the most disabling consequences of spinal cord injury (SCI), yet it remains unclear whether residual brain–bladder communication persists after injury and can be therapeutically strengthened. Here, we integrated analysis of a clinical SCI cohort with studies in a mouse model that recapitula...

Qiang Li, Wei Li, Jun-Kui Shang et al. · 0 citations
Open access Aug 2026

Injury-transduced oligodendrocytes modulate neuroinflammation and glial activation in diseased and non-diseased central nervous system

It is shown that OLs respond to demyelinating diseases by increasing the expression and secretion of serine protease inhibitor clade A member 3N (SERPINA3N), and that SerpinOLs represent a common population of injury-transduced OLs that contributes to CNS pathology beyond myelin production.

Yan Wang, Mei-Na Zhu, Joohyun Park et al. · 0 citations

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