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Review Open access Sep 2026

Targeting cancer-associated fibroblasts: therapeutic strategies, translational challenges, and future perspectives

Cancer-associated fibroblasts (CAFs) act as key drivers of cancer progression and therapeutic resistance within the tumor microenvironment, but their diverse and context-dependent functions complicate therapeutic targeting. The limited clinical efficacy of CAF-targeting therapeutics has prompted a critical reassessment...

Yan-Ping Jiang, Bo Ding, Han Yin et al. · 0 citations

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