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Author

Bohan Zhu

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Open access Sep 2026

Directing GABAergic neuronal identity from human iPSCs through developmental patterning.

GABAergic interneurons are implicated in numerous neurodevelopmental and neuropsychiatric disorders. Transcription factor (TF)-mediated induction of human pluripotent stem cells (PSCs) rapidly generates GABAergic neurons, yet their regional identity remains poorly defined. Here, we show that the chromatin state of the...

Rui-Qi Hu, Linda L. Boshans, Yi-Ran Tao et al. · 0 citations
Open access Jul 2026

Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis

These findings identify Uhrf1 as a central regulator that tightly couples DNA methylation maintenance to 3D genome organization during gastrulation, thereby, directing early lineage specification and positioning Uhrf1 as a pivotal mediator of epigenetic information transfer during early embryogenesis.

Agata Kurowski, Bohan Zhu, Yifei Sun et al. · 0 citations

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