Gut microbiota-derived SCFAs mediate the intestinal anti-aging effect of structurally characterized Dendrobium officinale glucomannan via Treg immune regulation in mice.
Intestinal aging is closely associated with gut microbiota dysbiosis and insufficient microbial short-chain fatty acid (SCFAs) production, particularly butyrate. Here, a homogeneous polysaccharide (DOPP) was isolated and purified from the stems of Dendrobium officinale Kimura et Migo, and its structural characteristics...