Bo Pang

Mitochondrial protein import stress in Parkinson’s disease: the TOM/TIM–PINK1/Parkin–DELE1/HRI axis linking mitochondrial proteostasis to neuronal death

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD), but how impaired mitochondrial homeostasis drives the selective death of dopaminergic neurons is still poorly understood. At the center of this problem lies the mitochondrial protein import machinery—the TOM and TIM23 translocases—which doubles as a s...