Jul 2026
Shank3b deficiency drives anxiety-like behaviors via impaired GABAergic inhibition and enhanced intrinsic excitability in the basolateral amygdala.
Impaired GABAergic transmission associated with reduced GABRA2 expression as a key mechanism underlying E/I imbalance and heightened neuronal excitability in the BLA of Shank3b-deficient mice is identified, which likely contributes to ASD-related anxiety-like behaviors.
Ruiting Li, Bo Wang, Hui-Ting Ren et al.
· Neuropharmacology · 0 citations