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Open access Sep 2026

A Spatial Multiomics Atlas and Resource for Immune-Fibrotic Niches in Chronic Kidney Allograft Dysfunction

Chronic allograft dysfunction (CAD) is a major cause of late kidney-allograft failure, yet its spatially organized cellular and metabolic mechanisms remain poorly resolved because human biopsies are scarce and experimental models are imperfect. Here, we established a tacrolimus-modulated accelerated mouse model of CAD...

Qiong-Qiong Gao, Zong-Pan Ke, Wen-Hao Xu et al. · 0 citations
Open access Sep 2026

Astragalus polysaccharides alleviate burn sepsis induced lung injury by suppressing the WTAP/m⁶A/PFKFB3 axis to reduce endothelial pyroptosis

Burn sepsis is a life-threatening complication of severe burns, characterized by pulmonary endothelial injury driving acute lung injury (ALI). Pyroptosis and vascular barrier dysfunction are key pathological in this process; however, their underlying mechanisms remain unclear. Astragalus polysaccharides (APS), a...

Wenqiang Liao, Xing Cheng, J. Zhan et al. · 0 citations

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