Bo-Wen Chen

Single-cell transcriptomic profiling reveals distinct vascular-associated microglia signatures in cerebral small vessel disease

Cerebral small vessel disease (CSVD) is a major cause of cognitive impairment, characterized by neuroinflammation and microvascular dysfunction. A specialized subset of microglia, known as vascular-associated microglia (VAM), intimately interacts with the cerebral vasculature and plays a pivotal role in mediating neuro...