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Author

Bo-Wen Ke

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2 papers indexed here

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Aug 2026

A pathogen-mimicking nanovaccine orchestrating danger recognition and immune activation for potent cellular immunity.

Vaccines protect against infectious diseases by mimicking pathogens and delivering key signals required for immune activation. However, how to rationally emulate pathogen invasion processes to achieve potent cellular immunity remains a major challenge in vaccine design. Here, we propose a pathogen-mimicking delivery st...

Shuting Bai, Tianyi Luo, Kun Xiong et al. · 0 citations
Open access Aug 2026

A multi-agent molecular optimization framework leads to a rapid-recovery intravenous anesthetic candidate with an improved safety margin

Lead optimization, the systematic refinement of therapeutic compounds through iterative structural modification, faces a dual challenge in modern drug discovery: navigating astronomically vast molecular design spaces while balancing conflicting demands on potency, pharmacokinetics, and safety. We present MASCOT (Multi-...

Zhe Xue, Wei Ai, Zhuang Miao et al. · 0 citations

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