ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma
Introduction Oral squamous cell carcinoma (OSCC) shows marked biological heterogeneity, but markers that connect malignant epithelial states with the tumor immune context remain limited. Origin recognition complex subunit 6 (ORC6) participates in DNA replication licensing, but its disease-specific role in OSCC is not w...