Syndecan-4 drives immune escape in microsatellite-stable colorectal cancer by suppressing the formation of cytotoxic effector T cells via the PRKCA–TNFα–NF-κB axis
Approximately 85% of colorectal cancers (CRCs) are mismatch repair proficient/microsatellite stable (pMMR/MSS), a subtype that is resistant to immunotherapy because of its immunosuppressive tumor microenvironment (TME). However, the molecular determinants underlying immune evasion in MSS-type CRC remain incompletel...