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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Bolin Chen

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Jul 2026

MAP1S limits autoimmune uveitis by suppressing Th17 differentiation through dual control of the EGR2-LCN2 axis and autophagic flux.

These findings establish MAP1S as a critical node integrating acetylation signaling of EGR2 and autophagic flux to govern LCN2 homeostasis and Th17 pathogenicity, revealing a promising therapeutic target for autoimmune uveitis and potentially other Th17-mediated diseases.

Ying-Jun Cai, Li-Hui Xie, Bowen Li et al. · 0 citations

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