Bone niche-driven antitumor immune failure in osteosarcoma: Mechanisms and therapeutic implications (Review)
An evidence-graded bone niche-driven framework of layered antitumor immune failure in OS is presented, in which the skeletal niche is not treated as a passive anatomical background but as a spatial and temporal organizer of immune-cell trafficking, myeloid remodeling, treatment-induced repair programs, systemic niche c...