Systematic profiling reveals broad G protein coupling and context-dependent modulation of cyclic AMP by the orphan receptor GPR139.
BACKGROUND AND PURPOSE G protein-coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear. This study aimed to systematically define the G pro...