Aging-driven transcriptional programs in diabetic kidney disease: multi-omics discovery of diagnostic biomarkers and drug-repurposing targets.
BACKGROUND Diabetic kidney disease (DKD) is the primary global cause of end-stage renal disease. However, the aging-related gene networks driving its progression remain unclear. METHODS In this study, we integrated bioinformatics and experiments to screen for age-related hub genes in DKD and explore their diagnostic...