From Genetic Variants to Immune Dysregulation: Multi-Omics Mendelian Randomization Decodes Molecular Networks in Rosacea.
BACKGROUND Rosacea is a chronic inflammatory skin disease with incompletely understood pathogenesis. OBJECTIVE This study aimed to identify key genes and regulatory mechanisms using multi-omics Mendelian randomization (MR) and machine learning, and to validate the findings in animal experiments. METHODS Bidirection...