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Open access Oct 2026

From Genetic Variants to Immune Dysregulation: Multi-Omics Mendelian Randomization Decodes Molecular Networks in Rosacea.

BACKGROUND Rosacea is a chronic inflammatory skin disease with incompletely understood pathogenesis. OBJECTIVE This study aimed to identify key genes and regulatory mechanisms using multi-omics Mendelian randomization (MR) and machine learning, and to validate the findings in animal experiments. METHODS Bidirection...

Meng Chen, Bo-Wen Tan, Jia He et al. · 0 citations
Review Aug 2026

Flavonoids in rosacea therapy: multi-target mechanisms from preclinical models to clinical translation

Flavonoids exert multi-target effects in rosacea via anti-inflammatory and vascular-modulating mechanisms and should prioritize advanced neuroimmune models, enhanced delivery systems, and patient stratification approaches to optimize clinical application.

Meng Chen, Xin-Ru Hu, Bo-Wen Tan et al. · 0 citations

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