Boya Shan

Divergent Disassembly of PrP106-126 Aggregates Driven by Isomeric Polyoxometalate Hybrids.

The misfolding and aggregation of the prion protein into amyloid fibrils is primarily driven and stabilized by hydrophobic interactions, rendering the aggregates highly resistant to disaggregation and posing a significant therapeutic challenge. To address this issue, we design two compounds by covalently grafting isome...