Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity. Developing effective ML pipelines for such data remains time-consuming and error-prone, while existing automated machine learning (AutoML) systems only partially address this challenge because they largely rely on brute-force search over predefined spaces and lack explicit reasoning and memory. We therefore reformulate AutoML for small clinical data from exhaustive search to reasoning-driven refinement. We propose DoctorAgents, an agentic AI framework that autonomously constructs and optimizes end-to-end ML pipelines through specialized large language model (LLM) agents for generation, validation, and refinement. DoctorAgents backpropagates natural-language feedback through textual gradient descent to perform targeted updates without exhaustive search. Experiments across diverse clinical tasks show that DoctorAgents consistently outperforms established AutoML baselines while producing more interpretable task-specific representations.
Ruilin Wang, Bozhong Wang, Elizabeth Kourbatski et al.· 1 citation
Memory is essential as language agents move from isolated tasks to long-horizon, stateful workflows, yet existing evaluations often reduce it to retrieval or question answering. We introduce ContextWeave, a longitudinal benchmark that evaluates whether recalled experience improves downstream agent performance in realistic office-work streams. ContextWeave reconstructs privacy-preserved, multi-month workflows of 14 participants into 1,005 executable tasks, including 568 core evaluation tasks, with instructions, containerized environments, trajectories, and task-specific rubrics. It measures workspace quality and alignment with participant-specific preferences, complemented by diagnostics of relevance, continuity, solvability, and robustness to misleading recall. Across six memory components under a fixed model, the strongest configuration raises Workspace Score from 68.08 to 78.20 and Preference Score from 41.50 to 70.60. With a fixed memory component, recall improves both outcomes for all five tested base models, although gains vary substantially. Our analysis shows that actionable, experience-rich memory supports workflow continuation and reduces redundant exploration more effectively than compact summaries, while it can also be more susceptible to misleading recall. These findings motivate memory systems that optimize not only retrieval relevance but also reliable use during execution.
Bozhong Wang, Yu Yao, Enxi Wang et al.· 0 citations