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Author

Bradley T. Christian

2 papers indexed here

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Open access Oct 2026

Plasma β‐synuclein associates with hippocampal synaptic density measured with [11C]UCB‐J PET and plasma tau markers in Alzheimer's disease

Abstract INTRODUCTION Plasma β‐synuclein is a promising blood‐based synaptic biomarker, but relationships with synaptic density as indicated by [11C]UCB‐J positron emission tomography (PET), and blood biomarkers of Alzheimer's disease (AD) pathology, neurodegeneration, and astrocyte activation need further characteriza...

Darby C. Peter, Max J. McLachlan, A. DiFilippo et al. · 0 citations
Oct 2026

EXPRESS: Synaptic density PET mediates the relationship between Alzheimer's disease pathology and cognitive performance.

INTRODUCTION Synaptic loss is one of the strongest post-mortem predictors of Alzheimer's disease (AD) severity and may impact how pathology affects cognition. This study compared regional [11C]UCB-J synaptic density across the AD continuum and evaluated the extent to which synaptic density mediates relationships betwee...

Max J. McLachlan, Brecca Bettcher, Rebecca E. Langhough et al. · 0 citations

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