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Author

Bradley T. Hyman

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Open access Aug 2026

α‐Synuclein strain homogeneity in multiple system atrophy subtypes

Abstract Conformationally distinct “strains” of α‐synuclein aggregates are believed to contribute to the clinical and pathological diversity observed among synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease. Cases of MSA can be classified into two distinct subtypes: the cerebellar variant,...

Heather H. C. Lau, N. R. G. Silver, Surabhi Mehra et al. · 0 citations
Open access Aug 2026

GFAP upregulation by astrocytes attenuates tau neurofibrillary tangle pathology in a mouse model of tauopathy

The upregulation of the intermediate filament glial fibrillary acidic protein (GFAP) by reactive astrocytes has been traditionally assigned structural functions such as the shaping of astrocyte morphology and the formation of the glial scar. However, in vitro studies have also implicated GFAP in chaperone-mediate...

C. Muñoz-Castro, Molly A. Healey, Ayush Noori et al. · 0 citations
Open access Jul 2026

Tau isoform imbalance and aggregation are pathological hallmarks of X-linked dystonia-parkinsonism

It is reported that X-linked Dystonia-Parkinsonism (XDP), caused by a non-coding retrotransposon-associated repeat insertion in TAF1, involves a significant imbalance of tau isoforms and the accumulation of hyperphosphorylated, four-repeat tau in the brain.

C. J. Reyes, Aloysius Domingo, E. Penney et al. · 0 citations

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