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Branden J. Lynch

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Jul 2026

Abstract A044: Dissecting the developmental trajectory of DICER1 syndrome-associated sarcoma with genetically engineered mouse models

A fibroblastic origin for DICER1 syndrome-associated sarcoma is uncovered and a faithful mouse model is established that provides a faithful mouse model for future mechanistic and translational investigation and identified that the MAPK pathway is activated along the progression of both mouse and human tumors.

Felix K. F. Kommoss, Joyce Yu-Han Zhang, Branden J. Lynch et al. · 0 citations